Advanced spectrophotometric chemometric methods for resolving the binary mixture of doxylamine succinate and pyridoxine hydrochloride
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چکیده
منابع مشابه
Simultaneous Determination of Doxylamine Succinate, Pyridoxine Hydrochloride and Folic Acid by Chemometric Spectrophotometry
Simultaneous estimation of three component tablets containing Doxylamine succinate (DOX), Pyridoxine hydrochloride (PYR) and Folic acid (FA) was carried out by UV spectrophotometric assisted chemometric methods. Four chemometric methods i.e. classical least square (CLS), inverse least square (ILS), principal component regression (PCR) and partial least squares (PLS) were applied to simultaneous...
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A simple and rapid UV – Spectrophotometric method was developed and validated for the simultaneous estimation of Doxylamine succinate and Pyridoxine HCl in combined dosage forms. The said combination is used in treating morning sickness associated with pregnancy. For the simultaneous estimation of both drugs, 260 nm and 285 nm were selected as wavelength of analysis. The linearity range was tak...
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Nausea and vomiting in pregnancy (NVP) is common and often undertreated, in part due to fears of adverse effects of medications on the fetus during early pregnancy. In April 2013, the US Food and Drug Administration (FDA) approved doxylamine succinate 10 mg and pyridoxine hydrochloride (a vitamin B6 analog) 10 mg as a delayed-release combination pill called Diclegis for the treatment of NVP. Di...
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Three methods are presented for simultaneous determination of ibuprofen and paracetamol without previous separation. The first method depends on first derivative UV spectrophotometry, with zero-crossing measurement. The first derivative amplitudes at 230 and 290 nm were selected for the assay of ibuprofen and paracetamol, respectively. The second method depends on first derivative of the ratio-...
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Three methods were developed for simultaneous determination of amlodipine and valsartan without previous separation. The first method depends on first derivative of the ratios spectra (DD1) by measurements of the amplitudes at 234.5 and 247 nm for amlodipine using 30μg/mL of valsartan as a divisor and at 282 and 292 nm for valsartan using 80μg/mL of amlodipine as a divisor. Calibration graphs w...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica
سال: 2018
ISSN: 1846-9558
DOI: 10.2478/acph-2018-0008